Teratogenic effects of pantothenic acid antagonists on animal embryos.
نویسندگان
چکیده
In 1946 Nelson and Evans (1) reported that pantothenic acid (PaA) deficiency in rats often resulted in the fetal death with resorption, and suggested the importance of vitamins in the development of embryos. Lefebvres-Boisselot (2) observed a high incidence of cerebral and ocular defects, digital hemor rhages and edema in the fetuses from PaA-deficient rats. In 1948 Ackermann and Taylor (3) first used antimetabolite in the study of nutrition in embryos. They studied the nutrition of niacin in the chick embryo, using an anti metabolite, 3-acetyl pyridine. The role of folic acid in the development of chick embryos was also studied by Karnofsky et al. (4), using aminopterin and 4-aminofolacin. According to Zunin and Borrone (5), similar anomalies as observed by Lefebvres-Boisselot were found in the offsprings of the rats
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ورودعنوان ژورنال:
- The Journal of vitaminology
دوره 7 شماره
صفحات -
تاریخ انتشار 1961